So, 60 seconds in a minute, 60 minutes in an hour, 24 hours in a day, 365 days in a year, and lets just give the extreme benefit on the doubt and say she's 100 years old.

She has to be penetrated 5,849,424,173 times each second. Five billion times a second since the day she was born.
So lets assume she's using all her viable holes. She has a mouth, a pooper, and a vagoober. Lets assume each one can fit two gamer dingly-dongs. So, divide the previous number by six and we have 974,904,028. Still almost a billion times a second for each hole.
Even assuming that penetration isn't the only method, and she's able to use her hands, jigglers, and... Eh, fuck it, behind the knee? Is that a thing? I don't know, lets assume it is. That gives her 5 more 'holes' to work with. Lets be a little more generous, and say she's able to somehow use the undersides of her jigglers, so we got 6. And, to be super generous, lets still say two per those holes.
324,968,009. That's about as generous as I can be. Three-hundred-million penetrations per second in 18 'holes'.